Clopidogrel Therapy and Cognitive Function Outcome

 
   Lead Investigator:    Bahar Niknejad
   Institution      :    Eastern Virginia Medical School
   E-Mail           :    niknejb@evms.edu
   Proposal ID      :    1388



   Proposal Description:
   Emerging data suggest age-related change in platelet function contributes to the pathogenesis of neurodegenerative diseases, including Alzheimers Disease (AD). Animal models, especially transgenic mice, have shown the potential to highlight the interaction between platelets and molecular mechanism in AD.     In this retrospective longitudinal study, we seek to investigate the effects of Clopidogrel on cognitive function, measured by Clinical Dementia Rating score and Mini-Mental State Examination. Further, we also look at the association between Clopidogrel and neuropsychological tests to evaluate specific cognitive domains across various age groups, ethnicities and gender to determine if demographic factors impact the medications efficacy in preserving cognitive function as different subpopulations have different rates of progression for AD. The primary outcome measures will be time to clinical event and change in MMSE score. The secondary outcome measure includes neuropsychological tests to evaluate specific cognitive domains. Findings from this study will provide insight in to the association between clopidogrel and cognitive function that may lead to prospective research submission for extramural funding to further examine this association.